Hi Greg, I am curious, those Native keys you refer, what they have to do if it's hotSpotible or not? Until now, didn't find any software that wasn't hotSpotible! At least the principal buttons, presets, etc... I just heard a youtube Native instruments complete 8 demo. to me sounded very nice. If it's a VST soft synth, I guess that some buttons at least are hotspotible! Use the inspector and also access with Jaws cursour, etc... Ask someone that sees to help you position the mouse and give it a try! Good luck ! kind regards, Rui