Hi. I had two sighted people look at it. We looked at ms config and did loads of other stuff with no success. I ran disk defrag, disk cleanup, reg scrub, no adware, Symantec, and I also tried running the machine with all hardware and internet connection unplugged. It didn't make much difference. It happens with every application, when running jaws or not. And, my machine is no longer under warranty. Any further advice? Thanks a lot for the suggestions so far guys. Regards, Cameron.